Funding academic, non-commercial clinical research
The Jon Moulton Charity Trust supports high-quality clinical trials across many therapy areas where clinical need is clear and conventional funding can be difficult to secure. Positive outcomes should be translated to clinical practice as fast as possible. Its principal aim is to fund non-commercial trials to make clinical advances and promote the relief of suffering.
£53mcommitted to clinical trials
170+clinical trials funded
100+published articles resulting from funded work
Clinical advances that relieve suffering
The Charity Trust was set up in 2018 to continue the work of the previous charity, the J P Moulton Charitable Foundation. To date, some £53 million has been committed to clinical trials by Jon Moulton CBE and these vehicles.
Clinical research awards
Since their inception, the charities have funded over 170 clinical trials which have been selected based on high quality science with the potential to have a direct benefit to patients. The trials have been conducted in a wide range of therapy areas including respiratory, women's health, oncology, cardiovascular, diabetes, multiple sclerosis, rare diseases, COPD, paediatrics and COVID-19.
The charities have supported ground-breaking research in diseases that struggle to obtain funding from other funders as they do not fulfil their funding criteria.
The quality of the trials funded is demonstrated by high rates of publication – some 16 publications of funded trials have been published in the Lancet.
Funding Calls
We are delighted to announce that the next funding round is now open for applications.
Applications must meet the following criteria:
- Be a clinical trial of a medicinal product, device or clinical procedure.
- Have a reasonable prospect of improving treatment.
- Will provide initial outcomes of the trial within 36 months of grant activation.
- Cannot be readily funded elsewhere.
We are aiming to fund up to ten projects based in the UK. All applications meeting the criteria above are welcome to apply. Applications from UK medical charities for co-funding would also be welcomed.
Applications should be submitted no later than 31st December 2026.
Funding decisions will be made by mid-February 2027.
There is no specific application form to complete.
How to Apply for Funding
Calls for funding are advertised in the Lancet and BMJ periodically. Successful applications will be funded by The Jon Moulton Charity Trust. Applications should initially be no more than 12 pages in length and should outline the following:
- Research title
- Contact details for the lead applicant
- The background and rationale for the trial
- The expertise and experience of the applicants
- A summary protocol including details of any devices, investigational medicinal products and statistical calculations
- A detailed budget and justification of costs
- A firm timescale for the duration of the trial, including realistic set-up, recruitment and analysis periods
- Any ethical or conflicts of interest issues
- Possible and desired outcomes
- Confirmation in writing to the Trustees that all findings from the trial will be made available for publication and efforts will be made for publication
- Confirmation in writing to the Trustees that no intellectual property generated from the trial will be retained for commercial exploitation other than with the prior written consent of the Trustees
Decision timingApplicants will receive a decision approximately 6 weeks after the submission deadline. Awardees will be expected to provide a final budget with calendarisation of expenditure, and progress reports are required every quarter.
Publications of funded research
Examples of publications resulting from funding can be accessed below. There are 91 linked publications and records from trials supported by the charity and predecessor foundation.
A multicentre randomized controlled trial of transabdominal vs transvaginal cervical cerclage
Does the addition of subcutaneous interferon-alpha 2b for 6 months only to the treatment of Behcet's disease significantly reduce the number of patients requiring immunosuppressive agents to control their disease over the following 2 years
Randomised, placebo-controlled trial of itraconazole in the treatment of Fungal-sensitised patients with severe asthma without ABPA
A pilot study of combination monoclonal antibody treatment in early active relapsing-remitting multiple sclerosis using Campath-1H and its non-binding form, SM3
Gastro-oesophageal reflux disease in chronic cough: a randomised controlled trial of medical versus surgical treatments
A randomised trial of botulinum toxin A versus placebo for refractory detrusor over-activity - RELAX study
AZALEP a randomized controlled trial of azathioprine to treat leprosy nerve damage and Type 1 reactions in India
Phase II trial of autologous dendritic cells transfected with a plasmid encoding melanocyte differentiation antigens using a non-viral delivery system for the treatment of patients with metastatic melanoma
The effect of thalidomide on cachexia in upper gastrointestinal cancer
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients
The role of minimally invasive surgery in unborn babies with lower urinary tract obstruction
Cranberry product versus low dose trimethoprim in the prevention of recurrent urinary infections in older women
Does remote ischaemic preconditioning reduce complications following major vascular surgery
Repair of Spinal Root Injury by Transplantation of Autologous Adult Olfactory Ensheathing Cells
Atorvastatin for preventing the progression of sepsis to severe sepsis (ASEPSIS Trial): a randomised, double-blind, placebo-controlled trial
A phase I/II clinical study of gene modified donor lymphocytes following haploidentical haematopoietic stem cell transplantation
Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis (MS-STAT)
Genetic factors and gene-environment interactions in the onset, persistence and severity of asthma
The Epistasis Project
Scavenging free haemoglobin attenuates the systemic inflammation response following surgery
Comparison of high flow versus titrated oxygen therapy in the emergency department management of St Elevation Myocardial Infarction Trial - OPTIMISE study
Cognitive function and surgical success following pulmonary endarterectomy - The PEACOG trial
Vitamin D and skeletal muscle weakness in chronic obstructive pulmonary disease
Superdose project - a community study investigating a dose relationship between neonatal BCG vaccination and risk of asthma and atopy in children - MANCAS Study
A randomised controlled trial of laparoscopic adhesiolysis on chronic pelvic pain
A randomised controlled trial of prednisolone for women with recurrent miscarriage and high levels of uNK cells in the endometrium
Muscle MRI in Congenital Myasthenia
Lentiviral Gene Therapy for inherited skin disease: Phase 1 testing of ex-vivo gene modified skin grafts in Netherton Syndrome
Is diabetes surgery effective and safe for the treatment of Type 2 Diabetes Mellitus?
Susceptibility to infections and exacerbations of asthma: markers and mechanisms
Avoiding mite allergen to prevent asthma exacerbations in children
Duration of Luteal Support with progesterone pessaries to improve success rates in assisted conception; a randomised controlled trial. (The DOLS Trial)
Production and First-in-Man Use of T Cells Engineered to Express a HSVTK-CD34 Sort-Suicide Gene
Cough responses to novel tussive agents in health and disease
CRASH 3
Defining defective acetylcholine receptor function for definitive diagnosis and appropriate treatments of congenital myasthenic syndromes
Reducing brain injury in babies by combining cooling therapy and xenon gas
Immunotherapy with CD19ζ gene-modified EBV-specific CTLs after stem cell transplant in children with high-risk acute lymphoblastic leukaemia
Promoting thymic rescue of lymphopenia in humans
Treatment of Premature Ovarian Failure
A pilot comparison of bladder awareness during filling and changes in sensation in white and Indian Asian Women
Genes, mechanisms, models and treatments for myasthenia
A study to investigate circadian biology of asthma
Phase IIa, randomised, open label, controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis PROteKT
Dietary nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary disease
Randomised Controlled Trial of Intermittent vs. Continuous Feeding on Skeletal Muscle Wasting During Early Critical Illness
GLP-1 Receptor Agonist interVention for poor responders after barIAtric Surgery
Simvastatin as a neuroprotective treatment for Parkinson’s disease – a double-blind, placebo controlled clinical learning study in patients of moderate severity. Part of The Cure Parkinson's Trust's linked clinical trials initiative
A randomised, controlled, pilot study examining neurally-adjusted ventilatory assist (NAVA) in patients at high risk of prolonged ventilatory failure during recovery from critical illness
A pilot trial for McArdle disease
Safety and feasibility of a clinical trial of permissive hypoxia in paediatric critical illness
INvestigating the lowest Threshold of vascular bENefits from LDL cholesterol lowering with a PCSK9 mAb InhibiTor (alirocumab) in healthY volunteers and patients with stable cardiovascular disease (INTENSITY)
The pathology of T cells in immune thrombocytopenia.
Algorithmic Protamine Dosing for Reversal of Heparin after Cardiopulmonary Bypass – The PRODOSE Trial)
NeuroSAFE: A single-blinded, multi-centre randomised controlled trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard RALP
A “decoy bypass” for treatment of obesity and diabetes
Vascularised sentinel skin flaps to detect rejection in lung and heart transplantation
Developing Tests for Endometrial Cancer detection (DETECT): protocol for a diagnostic accuracy study of urine and vaginal samples for the detection of endometrial cancer by cytology in women with postmenopausal bleeding
Pharmacokinetics of intramuscular tranexamic acid in trauma patients: a clinical trial
Maintaining Fitness during neoadjuvant Chemotherapy for oesophageal cancer: a feasibility study to investigate the utility of a simple, home–based, exercise intervention during chemotherapy.
Breath and plasma metabolomics to assess inflammation in acute stroke
Clinical trial to detect and rule out significant prostate cancer - Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study
Using INFOrmation Videos to Improve Patients’ satisfaction and experience in Endoscopy (INFOVIPE): Randomised Controlled Trial
A Phase I Clinical study to assess the safety and immunogenicity of a self-amplifying RNA (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID-19
The pathology of T cells in immune thrombocytopenia
Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study
A Double-Blind, Randomised, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease
Interim analysis of the T4 immunotherapy study
A precision medicine study to evaluate single nucleotide polymorphisms in the ET-1 pathway and other factors that maximise ET-1 receptor antagonist responses in microvascular angina
Cardiac MRI in the assessment of chronic thromboembolic pulmonary hypertension and response to treatment
Interim toxicity analysis from the randomised HERMES trial of 2- and 5- fraction magnetic resonance imaging - guided adaptive prostate radiation therapy
Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results
Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial
IgE-sensitization predicts threshold but not anaphylaxis during oral food challenges to cow's milk
Standard and Hypofractionated Dose Escalation to Intraprostatic Tumor Nodules in Localized Prostate Cancer: 5-Year Efficacy and Toxicity in the DELINEATE Trial
Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial
Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study
Bariatric Surgery in Women with Polycystic Ovary Syndrome
Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: the BAMBINI multicentre, open-label, randomised controlled trial
Progenitor cell-derived basophils: A novel barcoded passive degranulation assay in allergic diseases
Basophil Activating Factors in the Serum May Underlie the ‘Nonreleaser’ Basophil Status in the Basophil Activation Test
GABA and Glutamate in hMT+ Link to Individual Differences in Residual Visual Function After Occipital Stroke
Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms
Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms
Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial— The ABC-Sepsis Trial
Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT
Mexiletine versus lamotrigine in non-dystrophic myotonias: a randomised, double-blind, head-to-head, crossover, non-inferiority, phase 3 trial
Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial
MicroRNAs as Bile-based biomarkers in pancreaticobiliary cancers (MIRABILE): a cohort study
Contact
For enquiries about the Trust:
Please contact Helen Critchley by email at helen@jmcharitytrust.gg.
The Jon Moulton Charity Trust is registered in Guernsey with registered charity number CH605.
Fourth Floor, Plaza HouseAdmiral Park
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